【摘要】 目的 研究原发性高血压(eh)患者血清c型利钠肽(cnp)水平的变化,分析其与高血压分期和靶器官损害的关系。方法 放射免疫分析检测97例eh患者和50例正常健康人的血清cnp水平。结果 eh组血清cnp显著高于对照组,1、2、3级eh患者血清cnp水平呈升高趋势,且伴有心脑肾并发症组cnp水平高于无并发症组,各组间比较均有统计学意义,p<0.05。结论 cnp水平与高血压病情进展、靶器官损伤程度密切相关。
【关键词】 原发性高血压;c型利钠肽;放射免疫分析
change of serum c-type natriuretic peptide level in patients with essential hypertension
guo chang-lei,li hong-jun.department of cardiology,the first affiliated hospital of xinxiang medical college,henan 453100,china
【abstract】 objective to explore the change of serum level of c-type natriuretic peptide in patients with essential hypertension and to evaluate the relationship between the serum level of c-type natriuretic peptide and stage of hypertension as well as target organ injury. methods the serum level of c-type natriuretic peptide were determined with radioimmunossay in 97 eh patients and 50 controls. results the serum levels of c-type natriuretic peptide in eh patients were significantly higher than those in controls. the serum levels of c-type natriuretic peptide increased gradually fromgrade 1 to grade 3 eh. the serum levels of c-type natriuretic peptide in patients with renal and/or cardio and/or cerebral vascular complications were significantly higher than those in patients without complications.the differences were significant,p<0.05. conclusion the serum level of c-type natriuretic peptide in eh patients were closely related to the severity of eh process and target organ injuries.
【key words】 essential hypertension;c-type natriuretic peptide;radioimmunossay
doi:10.3760/cma.j.issn 1673-8799.2010.11.29
作者单位:453100新乡医学院第一附属医院心内一科
本文对97例原发性高血压患者的血清cnp水平进行检测,以探讨血清cnp与高血压分期及并发症的关系。
1 材料与方法
1.1 一般资料 选取我院2008年10月至2010年4月收治的97例初诊为原发性高血压患者作为高血压组,诊断标准见2005年《
